The paper details the application of the sleep events search algorithm based on "histograms analysis" method. The algorithm will be used for the "body movement" sleep event detection. This event search priority and actuality is caused by its close connection with other events, as will be discussed in more detail in the relevant section of the article. The main problems arising in this method usage and their solutions are described. Phased method structure is discloses, where each phase is represented as a separate item with detailed comments. A comparative analysis of the results obtained with the automatic search with pre-spaced events manually is made. Conclusion on the basis of the experiment and recommendations for further method development are made.

Keywords:

The paper describes the principles of the use of audiovisual stimulation for the treatment of hypertension is shown. Proposed to increase the effectiveness of therapy to use feedback on the state of the patient , which controls the frequency of audio-visual stimuli , depending on the magnitude of blood pressure and the vegetation index.

Keywords: hypertension, sensorineural therapy , feedback, vegetative index , blood pressure, pulse audio-visual stimuli

Intracellular microinjection - a method of direct introduction of cellular organelles and solutions of substances into living cells. The technique of microinjection into nerve cells by puncturing their processes - axons , which are often surrounded by a dense glial sheath, are described. To puncture the sheath a special injector transmitting microvibrations of ultrasonic frequency on the injection capillary was designed. The results of using the proposed microinjection technique for introducing fluorescent marker in large axons of model object - crayfish ventral nerve cord, to visualize the morphology of axons, were shown.

Keywords: intracellular microinjection, neuron, axon, glial sheath, ultrasound vibration, piezoelectric transducer

The authors suggest two approaches to constructing hypotheses about the interactions of proteins on the basis of the results of tracking the changes in their levels during the studied biological process. The first approach is based on the use of machine mining of biological texts, which are freely available on the Internet. The second is related to the execution of database queries on binary protein-protein interactions . To specify the experimental context in obtained protein networks, filtering of the protein entities on the basis of needed ontology from database Gene Ontology was used.

Keywords: text mining, data base, protein-protein interaction, protein networks

The article deals with interference suppression algorithms that arise in the ECG signal by moving of the electrodes due to the motion of the object. It is proposed to use an adaptive filter, which reference signal is provided by the data triaxial accelerometer.

Keywords: electrocardiogram, adaptive filtering, motion artifacts, electrophysiological signal adaptation algorithm

Considered part of the software and hardware designed and manufactured the device for the automatic analysis of nonlinear parameters of high-temperature superconducting ceramics YBa2Cu3O7-x in variable magnetic fields. Shows the calibration and specifications. The new is a synchronous (the error in determining the phase of no more than 0.5%) of digital signal samples of the nonlinear response of the sample and the samples generated by an external magnetic field (the error is less than 1%), with the number of data samples per channel to 90 ∙ 106 12-bit samples and sampling 600 ∙ 103 samples per second. The reference range of variable magnetic fields 1 - 50 Oe, a frequency range of 1 - 50 kHz in steps of 1 Hz and the accuracy of 0.0291 Hz. The device has an interface to the computer via two USB-interface and original software to work with it. With the use of the device, a series of experiments designed to produce some non-linear parameters of cylindrical sample made of high-Tc ceramic YBa2Cu3O7-x. The analysis of the results and their comparison with the presented in the literature  

Keywords: Nonlinear medium, high-temperature superconducting ceramics, synchronous samples, harmonics, ARM-9 CPU, a differential sensor.

  We have investigated electrical and gas sensitive properties of gas sensor based on carbon nanotubes (CNT) and carbon nanotubes modified by metal oxides (such as tin oxide and silicon oxide).  Also we  have find out that modification of  CNT by  metal oxides helps to  improve film`s adhesion to substrate, decrease electrical resistance, recovery time, working temperature , enhance gas sensitivity in comparison with sensitive elements based  only on CNT or metal oxides. Moreover experimental results showed that properties of composite material depend on concentration correlation of solutions. As a result we can get highest sensitivity of sensor element by choosing optimal relation between concentrations of solutions.

Keywords: Сarbon nanotubes, modification, tin oxide, silicon oxide, gas sensor

  Work is connected with the synthesis of information behavior of groups of autonomous intelligent agents of biomedical research, and machine learning methods to ensure the reliability of the forecast increase in their behavior using multi-agent systems based on the use of bionic principles, methods and models of swarm intelligence. Developed multi-agent system simulates the behavior of groups of autonomous intelligent agents developed methods to meet the proposed criteria of reliability, differing form the structure of the system and developed a set of specialized agents that provides the capability to model a group of biomedical robotics using autonomous intelligent agents. Classifier of stabilographic signals on the basis of Parzen method was developed. These data indicate that the auxiliary symptoms resulting from multidimensional scaling much more informative initial attributes.

Keywords: Intelligent agent, multidiagnostics, Parzen classifier

  The mathematical features of construction information and measuring health systems (IMS). Because biological systems are complex, not always well-defined structure, for their correct description and implementation of metrological analysis requires its imposition. Accordingly, the presentation described bioinstrumentalnoe MIS. Within the theory of metrological synthesis formulated the concept of IMS core. With the use of the mathematical theory of categories and object-oriented modeling describes the basic relationships between the elements of the core IMS. The basic position with regards to the construction of MIS based on its structure. A scheme of the developed system of environmental monitoring of water environment on the basis of an integrated assessment of water quality. The main components of the system were presented. Feature of the developed system is the consideration of non-fixed sources of pollution, which was made possible thanks to the developed method of integral evaluation.

Keywords: Measuring health system, object-oriented modeling, method of integral evaluation

  The requirements to be met by a data acquisition system in terms of each of the problems to be solved. Presented electric concept developed biopotential amplifier with a total gain of 2000. The theoretical model of the spectrum of RR intervals and changes depending on the running processes. The analysis revealed that the resulting spectrum satisfies the conditions considered in the theoretical model, and can be further analyzed with fractal characteristics.

Keywords: Instrumental amplifier, biopotential, fractal index

  The purpose of investigation is to examine the effect of adaptation to difficult-house physical stress on the regulation of the vertical posture of man. For the analysis of the ability to maintain a vertical position used stabilographic hardware-software complex "Stabilan-1-02" (JSK Rhythm ", Russia). The ability to maintain a vertical position was evaluated in two static positions: 1) the main stand (OS) in the presence and absence of visual information, and 2) dip (PP) in the presence of visual information. Revealed that an increase of physical performance ability to maintain balance in static positions, especially in the complicated conditions (deprivation of visual information and static muscle tension) increases.

Keywords: Sports stabilometry, adaptation, vertical pose

  Regarding the structural evaluation of the instrumental error of bio MIS tool software package was developed that allows to take into account the error in the analysis of clinical diagnostic measurement in hematology research. It allows to analyze the results of hematological measurements with the measurement error and issue you with a message that characterizes getting results within normal or unreliability. Nanoparticles in biomedical analytical measurements are used as contrast agents, since, being immobilized specific proteins with adhesion to the diseased cells and bacteria. Register ultrasonic signal produced when the laser blood flow to the entered nanoparticles allows the detection and enumeration of diseased cells. The block diagram of analytical studies was designed to prove its basic metrological characteristics. Research is conducted in the centers for collective use of the Southern Federal University "Nanotechnology" and "Laser Technology", equipped with modern and unique nanotechnology research equipment.

Keywords: Bio MIS, nanoparticles, hematological measurements

  Various non-invasive assessment of psycho-physiological and emotional state were analyzed: the fractal estimation of speech signals, the analysis of rhythmic EEG patterns and computer stabilometry. The results allowing  prediction of the transition of the individual in a particular state, were obtained and objective criteria for determining the individual personality as a specialist were identified.

Keywords: Emotuonal speech, EEG pattern, attractor, suggestibility

  In this paper we consider the application of digital signal processing techniques to clean them from interference and to present in a special basis, which allows the detection of events related to the manifestation of the functioning of a functional system in health and disease. Implemented mathematical foundation and rapid synthesis methods for converting the signals used in electrophysiology based on the discrete wavelet and Gabor transforms. Filter synthesis using Filter Desing ToolBox package MatLab was observed. 

Keywords: digital signal processing techniques, rapid synthesis methods, discrete wavelet transform, Gabor transform

  Bbiomechanical parameters of the competitive exercise «bench» during the All-Russian competitions (Cup of Russia, Sochi 2011) were revealed in powerlifting athletes of various qualifications with motor disorder. Comparative analysis showed that there are significant differences between athletes of high, medium and low skills.

Keywords: Powerlifting, sports techniques, sportsmen of different qualifications with motor disorder

  New devices and equipment, which use the methods and facilities of computer stabilography, are introduced in the paper. These devises and equipment require improving power and speed-power rates of sportsmen in Russian Olympic and Paralympics National Teams. The article examines new technologies, which enable to estimate objectively the dynamics of training program’s effectiveness, during training of sportsmen for competition. In the paper is introduced an ability of use of these devices on the basis of new technologies under visual feedback for development of dose muscle force and motor function of the sportsman as well as for rehabilitation after overtraining, injury or trauma.

Keywords: Speed-power training, stabilography, dynamometry, moment of force

  Method of an automatic recognition of sleep events is described. The method is based on analysis of amplitude histograms that are built on each of registered channels. The method is designed for sleep events, distinctive feature of which is expressed amplitude change that appears simultaneously on several channels. For example, "General body movement" and "Limbs movement" events. But this is not limited; method can be applied to other events, for example "Snore". Algorithm can be divided into three stages: histograms building and analysis, vertical analysis, results processing.

Keywords: PSG, sleep events, histogram, detection algorithm

  The components of force plate signals, generated by cardiac activity, are investigated. The person stays in an ortograde posture, sit in the relaxed pose and in a pose at which the trunk keeps vertically and don’t contact with seatback. On the basis of a spectral approach features of power plate “Stabilan” indications and hardware-software complex «A multifunctional chair» are analyzed at inspection of the person holding set postures in different functional conditions (before and after physical activity). It is shown that change of vertical force (ballistogramm data) is an integrative signal. Manifestation of muscular components in force plate signals for an ortograde posture and a human pose sitting with vertical trunk are discussed.

Keywords: Force plate vertical signal, cardiac activity, posture stabilization

This article describes the method of registration electrocardiogram and physical activity which patient feels during the examination process. The represented scheme of research with registration of a load, which includes portable pulsometer, cardioregistrator fixing electrocardiogramm, frequency of cardiac contractions, ST segment shift, the trainer is a stepper to wichpeddal a block of load registation is connected. The person on stepper, tests a load peer to potential energy, spent during research. On the basis of the specified method the hardware-software complex of registration of a load is developed for functional diagnostics, there is a block diagram presented.

Keywords: Holtermonitor, ECG, physical activity

The problems of visual perception whole object are considered in the paper. As an objective method to explore these issues, are used as incentives figure in subjective contours - Kanizs figures. The survey was attended by eight healthy men (SFU students and staff), right-handed, aged 22 to 35 years. The results of analysis of variance characteristics visual EP, recorded in the perception of different figures, showed that significant differences were found when comparing the real and illusory form with a figure control.

Keywords: Visual perception, Kanizs figures, evoked potentials (EP), dispersion

The problems of the synthesis test biotechnological systems for assessing important professional qualities, the training and the actual state of the human operator of complex information systems. For this purpose is proposed to use computer reflexive games, built on the basis of measuring graphics, which take into account the properties of human visual analyzer. They help to create working situations of varying complexity, the on-line information presentation device. These systems can easily be adapted for studies of group activities, you only need to choose the type of test image.

Keywords: Biotechnical systems, reflexive games, measuring graphic, group activities

Briefly discussed the theoretical model of the spectrum of RR intervals and its changes depending on the processes taking place. Made a device for measuring cardiointervalogramms (CIG). Obtained from the renting of data, of varying duration and frequency shall be recorded for further processing. The analysis revealed that the resulting spectrum satisfies the conditions considered in the theoretical model, and can be further analyzed with fractal characteristics. Such an analysis is of great importance in the diagnosis of the patient directly to the duration of the therapeutic procedure for the optimization of both time and intensity exerted influence.

Keywords: CIG; fractal series; the spectrum of RR intervals

In the article is examined a hardware program complex on the basis of original sensors of power. This complex makes possible to register breath, pulse and locomotor activity of seriously ill bedridden patients and patients in coma without direct skin contact of sensors and patient for comfortable monitoring. The results of engineering tests are given. The exceptional indicator of system is a load capacity equal to or more than 500kg under the minimum grade value 10 gr. for every sensor. In the paper is demonstrated an availability of this complex for clinical medicine, computer stabilography, polysomnography and top level sport. In conclusion are pointed goals for further development of this complex.

Keywords: Stabilegraphy, polysomnography, strain-gauge-type power sensor, sport, comatose state

One of the most widespread endocrine diseases in the world is diabetes therefore its true diagnostics, and also diagnostics of its complications (encephalopathy, complications in cardiovascular system, etc.) is always actual. During carrying out research the analysis of psychological testing of examinees was carried out. Also in this work the attention is paid to application of methods of the statistical analysis for classification of EEG of patients by diabetic encephalopathy and healthy examinees. The most informative indicators of EEG reflecting cognitive functions of a brain were revealed. The interrelation of results of psychological testing and EEG analysis is established.

Keywords: electroencephalography, diabetic encephalopathy, discriminant analysis

In article the new model of interaction of functional systems of various hierarchical levels is offered: from unicell level, to level over social objects. Feature of model is introduction in its structure: perception filters, the accounting of a strong-willed component, convenience of its application not only in the field of physiology, but also in sociology, psychology, value logy and other sciences describing behavior of reasonable objects. The analysis of signals carrying out exchange of information between functional systems of different level of hierarchy is carried out. The offered model allows explaining and predicting many psycho physiological patterns accompanying conditions of expanded consciousness, and arising at activation of reserve possibilities of the person.

Keywords: functional systems, super consciousness, activation of reserve possibilities